The look and health of our skin can significantly affect our self-confidence. Visible imperfections such as acne, fine lines and blemishes can often make it difficult for us to feel attractive. Many of us find it a challenge to see ourselves in the mirror as we notice our skin and appearance aging. Unhealthy or damaged skin can also indicate internal problems, impacting emotional and mental well-being. It is well-documented that skin disorders can lead to lower self-esteem, whereas the opposite is true of healthy skin, our confidence is increased, social interactions become easier and we feel more beautiful.
The most common skin disorders include:
- Acne: Affects up to 50 million Americans annually, usually beginning in puberty and affecting many adolescents and young adults
- Atopic Dermatitis (Eczema): A chronic condition that causes dry, itchy skin and is very common in children
- Psoriasis: A chronic autoimmune condition characterized by patches of raised, reddish skin covered with silvery-white scale
- Rosacea: A common skin disease that affects millions of Americans
- Skin Cancer: The most common cancer in the United States, with melanoma being especially dangerous
Some less common skin disorders that may benefit from raising glutathione levels include:
- Vitiligo: Research has indicated that lower levels of glutathione in the blood or skin of vitiligo patients may be relevant to the condition. Glutathione maintenance is crucial for the survival of melanocytes, and its role in vitiligo has been a subject of study
- Hyperpigmentation: Glutathione has been considered a potential treatment for hyperpigmentation and has been studied for its skin-lightening effects. However, the evidence regarding its efficacy and safety for this purpose is still a topic of research and debate
- Epidermolysis Bullosa (EB): A study has suggested the benefits of raising glutathione in the modulation of keratin expression, which is relevant to the abnormal skin fragility observed in EB
BENEFITS FOR SKIN
Glutathione is known for its use in skin lightening, but the benefits of raising it at cellular level has many applications, including:
- Anti-aging Effects: Glutathione can reduce wrinkles and increase skin elasticity, contributing to anti-aging effects.
Glutathione and its antiaging and antimelanogenic effects https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413479/
- Melanin Regulation: Glutathione plays a role in the production of melanin, and studies have demonstrated its ability to reduce the production of melanin, leading to a more even skin tone and reduced appearance of dark spots.
Glutathione Peroxidase Level in Patients with Vitiligo: A Meta-Analysis
Molecular mechanism(s) for UV-B irradiation-induced glutathione depletion in cultured human keratinocytes https://pubmed.ncbi.nlm.nih.gov/15244506/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863094/
- Improvement of Skin Conditions: Glutathione’s antioxidant properties can help improve various skin conditions, such as psoriasis, by reducing oxidative stress and supporting the immune system.
Psoriasis Improvement in Patients Using Glutathione-enhancing, Nondenatured Whey Protein Isolate: A Pilot Study https://pubmed.ncbi.nlm.nih.gov/24155989/
Decrease in glutathione may be involved in pathogenesis of acne vulgaris https://pubmed.ncbi.nlm.nih.gov/21896138/
Oxidative Stress in Atopic Dermatitis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4781995/
Glutathione: a key player in autoimmunity https://www.ncbi.nlm.nih.gov/pubmed/19393193
Analyses in blood of dermatological patients. I. Glutathione and glutathione reductase https://pubmed.ncbi.nlm.nih.gov/1225656/
Glutathione maintenance is crucial for survival of melanocytes (Vitiligo) after exposure to rhododendrol https://onlinelibrary.wiley.com/doi/full/10.1111/pcmr.12494
The critical role of glutathione redox homeostasis towards oxidation in ermanin-induced melanogenesis https://www.sciencedirect.com/science/article/abs/pii/S0891584921007371
Differential Modulation of Keratin Expression by Sulforaphane Occurs via Nrf2-dependent and -independent Pathways in Skin Epithelia https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993737/
Glutathione the master antioxidant – Beyond skin lightening agent https://journals.lww.com/pigi/Fulltext/2021/08030/Glutathione__The_master_antioxidant___Beyond_skin.3.aspx
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DISCLAIMER : This information is not intended to diagnose, treat or prevent any disease. Please consult with your healthcare provider
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